This pattern is characterized by decorated cytoskeletal fibers, sometimes with small, discontinuous granular deposits. Typical staining show striated actin cables spanning the long axis of the cells. e.g. anti-actin, anti-non-muscle myosin.
Cytoplasmic fibrillar filamentous
Staining of microtubules and intermediate filaments spreading from the nuclear rim. e.g. anti-cytokeratin, anti-vimentin.
Cytoplasmic fibrillar segmental
Enhanced decoration of short segments, periodic dense bodies, along the stress fibers. e.g. anti-alpha-actinin, anti-vinculin, anti-tropomyosin.
Cytoplasmic discrete dots/GW body-like
GW body, processing body, lysosome*
Staining of GW bodies in the cytoplasm of interphase cells with high numbers in late S/G2 cells. e.g. anti-GW182, anti-Su/Ago2.
Cytoplasmic dense fine speckled
The pattern appears cloudy, almost homogeneous throughout the cytoplasm. e.g. anti-PL-7.
Cytoplasmic fine speckled
Scattered small speckles in the cytoplasm mostly with homogeneous or dense fine speckled background. e.g. anti-Jo-1.
Coarse granular filamentous staining extending throughout the cytoplasm. e.g. anti-mitochondrial antibodies.
Discontinuous speckled or granular perinuclear ribbon-like staining with polar distribution in the cytoplasm. e.g. anti-giantin, anti-golgin-245.
Rods and rings
Distinct rod and ring structures in the cytoplasm of interphase cells. Some smaller rods and rings also reported in the nucleus.