ICAP

HEP-2 CIC PROJECT

Update of an ongoing ICAP project - Clinical and Immunologic Characterization of HEp-2 IFA patterns (The HEp-2 CIC project)

Despite the worldwide acceptance of ICAP recommendations by clinical laboratories, academic institutions, and in vitro diagnostic industries, there is still considerable heterogeneity regarding the interpretation and reporting of HEp-2 IFA among different laboratories.

The scientific publications regarding the prevalence of HEp-2 IFA results are most frequently based on local/regional data, making it difficult to accurately register differences in the frequency of positive HEp-2 IFA tests and each HEp-2 IFA pattern in different parts of the world.

The HEp-2 CIC project aims to categorize and quantify the spectrum of heterogeneity in several aspects of the HEp-2 IFA test in laboratories worldwide.

Participating laboratories were invited aiming to obtain global geographical representation, including all continents (see below the representative world map). The coordinator of the immunology section identification of candidate laboratories filled out a structured form with relevant information on the HEp-2 IFA operation in the lab.

In addition, each participating laboratory provided complete data on the HEp-2 IFA result for all patients tested from January 1st to December 31st, 2019, without personal information of the patients. Data obtained from the participating laboratories were transferred to a structured database that allowed the comparison and harmonization of data from different laboratories.

To date, the HEp-2 CIC project obtained 464,161 results of the HEp-2 IFA test from 42 laboratories in 30 countries and five continents.

These results were analyzed and compared, and preliminary results were presented at the 13th International Congress on Autoimmunity, from June 8 to June 13 in Athens, Greece.

Both abstracts, as well as the participants’ list, can be seen below.

COORDINATORS

Luis Eduardo C. Andrade, MD, PhD
International Consensus on ANA Patterns (ICAP), Autoantibody Standardizing Committee, International Union of Immunological Societies. Federal University of Sao Paulo, Rheumatology Division, Department of Medicine, Sao Paulo, Brazil.

Trischna Martins
Federal University of Sao Paulo, Rheumatology Division, Department of Medicine, Sao Paulo, Brazil.

For additional information on any queries, please contact the coordinators at [email protected]

Members

Ilidio Abreu Hospital Dr. Nelio Mendonca, Servico de Patologia Clinica, Madeira, Portugal
Jamil Al-Mughales King Abdulaziz University, Faculty of Medicine Diagnostic Immunology Division, Jeddah, Saudi Arabia
Luis Andrade International Consensus on ANA Patterns (ICAP), Autoantibody Standardizing Committee, International Union of Immunological Societies.
Elaine Au Queen Mary Hospital, Division of Clinical Immunology, Department of Pathology, Hong Kong, Hong Kong PRC
E. Umit Bagnacik Gazi University Faculty of Medicine, Department of Immunology, Ankara, Turkey
Nancy Barrera Fundación Instituto de Reumatología Fernando Chalem, Laboratorio Clínico, Bogota, Colombia
Martin Bluethner MVZ Laboratory PD Dr. Volkmann Colleagues, Laboratory, Karlsruhe, Germany
Dimitrios P. Bogdanos Faculty of Medicine, University of Thessaly, Laboratory of Rheumatology and Clinical Immunology, Larissa, Greece
Ronald A. Booth Ottawa Hospital, EORLA & University of Ottawa, Ottawa, Canada
Fabiano Brito LAC-Laboratorio de Análisis Clínico, Inmunologia, Montevideo, Uruguay
Gabriel Carballo Hospital Carlos G. Durand, Laboratory of Immunology, Buenos Aires, Argentina
Amira Cerimagic Medical Faculty of Medicine, Department of laboratory diagnostics, Sarajevo, Bosnia and Herzegovina
Edward K.L. Chan University of Florida, Department of Oral Biology, Florida, United States of America
Daniela Cihakova John Hopkins University, Department of Pathology, Baltimore, United States of America
Karsten Conrad Technical University of Dresden, Institute of Immunology, Dresden, Germany
Jan Damoiseaux Maastricht University Medical Center, Central Diagnostic Laboratory, Maastricht, Netherlands
Kolter Freidhof Mayo Clinic College of Medicine, Laboratory, Rochester, AL, United States of America
Marvin Fritzler University of Calgary, Cumming School of Medicine, Calgary, AB, Canada
Keying Fu Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Medical Laboratory Center, Hainan, China
Ignacio Garcia de la Torre Universidad de Guadalajara, Department of Immunology and Rheumatology Hospital General de Occidente, Guadalajara,Mexico
Ranjan Gupta All India Institute of Medical Sciences, Dept. of Rheumatology, New Delhi, India
Manfred Herold Medical University of Innsbruck, Department of Internal Medicine II Rheumatology Laboratory, Innsbruck, Austria
Marcos Lopez Hoyos Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Spain
Maria Infantino Ospedale San Giovanni di Dio, Laboratorio Immunologia e Allergologia, Azienda Usl Toscana Centro, Dipartimento di Medicina di Laboratorio, Firenze, Italy
Ricky Ip Queen Mary Hospital, Division of Clinical Immunology, Department of Pathology, Hong Kong, Hong Kong PRC
Andres Mendiola Jimenez Hospital Universitario de la UANL, Servicio de Reumatología, Monterrey, Mexico
Resul Karakus Gazi University Faculty of Medicine, Department of Immunology, Ankara, Turkey
Abid Karim The Medical School, Clinical Immunology, Birmingham, United Kingdom
Werner Klotz Medical University of Innsbruck, Department of Internal Medicine II Rheumatology Laboratory, Innsbruck, Austria
Vathany Kulasingam University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada
Diana Landoni LAC-Laboratorio de Análisis Clínico, Inmunologia, Montevideo, Uruguay
Sergey Lapin Pavlov First Saint Petersburg State Medical University, Laboratory for Diagnosis of Autoimmune Diseases, Saint Petersburg, Russian Federation
Laurence Lutteri Liège University Hospital, Department of Clinical Chemistry, Liège, Belgium
Mariangela Manfredi Ospedale San Giovanni di Dio, Laboratorio Immunologia e Allergologia, Azienda Usl Toscana Centro, Dipartimento di Medicina di Laboratorio, Firenze, Italy
Cristóvão Mangueira Hospital Israelita Albert Einstein, Laboratory, Sao Paulo, Brazil
Mercedes Menendez Hospital Británico, Laboratorio, Montevideo, Uruguay
Khaled Mtewally Lupus Medical Laboratory, Laboratory, Cairo, Egypt
Tsuneyo Mimori Takeda General Hospital, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto, Japan
Lucile Musset CHU Pitié Salpêtrière-Ch Foix, APHP, Département d’Immunologie, UF immunochimie & autoimmunité, Paris, France
Eszter Nagy National Institute of Locomotor diseases and Disabilities, Department of Laboratory Medicine, Budapest, Hungary
Ran Nakashima Takeda General Hospital, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto, Japan
Carlos A. Núñez-Alvarez Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Laboratorio, Mexico City, Mexico
Scott Pereira Health Services Laboratories, Pathology, London, United Kingdom
Kerri Prain Autoimmune-Immunobiology Laboratory, Immunology Department, Queensland, Australia
Nadja Roeber Technical University of Dresden, Institute of Immunology, Dresden, Germany
Emir Rondo Medical Faculty of Medicine, Department of laboratory diagnostics, Sarajevo, Bosnia and Herzegovina
Johan Rönnelid Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden
Ola Saati King Abdulaziz University, Faculty of Medicine Diagnostic Immunology Division, Jeddah, Saudi Arabia
Ulrich Sacks Universität Leipzig, Medizinische Fakultät, Klinische Immunologie, Leipzig, Germany
Sofiane Samir Salah University Hospital of Mustapha Bacha, Immunology Department, Algiers, Algeria
Lorena M. Santafé Sarzosa Synlab solutions in diagnostics, Bioquimica Clinica, Quito, Ecuador
Minoru Satoh University of Occupational and Environmental Health, School of Health Sciences, Kitakyushu, Japan
Lusia Sepiaschvilli The Hospital for Sick Children/ University of Toronto, Paediatric Laboratory Medicine, Toronto, ON, Canada
Melissa R. Snyder Mayo Clinic College of Medicine, Laboratory, Rochester, United States of America
Mohsen Tanfus CHAUR-centre hospitalier affilié universitaire, MCQ-Mauricie centre du Quebec, Quebec, Canada
Anne Tebo University of Utah Health; ARUP Laboratories, Department of Pathology, Salt Lake City, United States of America, Current institution: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States Of America
Carolina Valenzuela Instituto de Salud Pública de Chile, Laboratorio Nacional y de Referencia de Inmunología, Santiago, Chile
Lieve Van Hoovels OLV Hospital Aalst, Department of Laboratory Medicine, Aalst, Belgium
Martine Vercammen Sint-Jan Hospital, Brugge/Oostende, Department of Laboratory Medicine, Brugge, Belgium

Map

World Map Participants

Downloads

CLINICAL AND IMMUNOLOGICAL CHARACTERIZATION OF HEP-2 PATTERNS (HEP-2 CIC PROJECT) - FREQUENCY OF NUCLEAR PATTERNS IN HEP-2 IFA DIFFER IN LABORATORIES WORLDWIDE Abstract 873; Poster 229. International Congress of Autoimmunity - Athens, Greece 2022
HEP-2 CIC PROJECT: HETEROGENEITY IN OPERATIONAL PROCESSING AND REPORTING RESULTS OF IFA HEP-2 PATTERNS WORLDWIDE. Abstract 968; Poster 230. International Congress of Autoimmunity - Athens, Greece 2022
POSTER CLINICAL AND IMMUNOLOGICAL CHARACTERIZATION OF HEP-2 PATTERNS FREQUENCY OF NUCLEAR PATTERNS IN HEp-2 IFA DIFFER IN LABORATORIES WORLDWIDE - Poster 229. International Congress of Autoimmunity - Athens, Greece 2022
POSTER HETEROGENEITY IN OPERATIONAL PROCESSING AND REPORTING RESULTS OF HEp-2 IFA PATTERNS WORLDWIDE - Poster 230. International Congress of Autoimmunity - Athens, Greece 2022
 
 
Online since 19 May 2015