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| Previous Nomenclature | None |
| Description | Discontinuous speckled or granular perinuclear ribbon-like staining with polar distribution in the cytoplasm. e.g. anti-giantin, anti-golgin-245. |
| Antigen Association | giantin/macrogolgin, golgin-95/GM130, golgin-160, golgin-97, golgin-245 |
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Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
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▶ Found in small numbers of patients with a variety of conditions ▶ Antigens recognized include giantin/macrogolgin and distinct golgin molecules; specific immunoassays to detect autoantibodies directed to specific Golgi antigens are currently not commercially available (85) |
| First level information references |
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85. Stinton LM, Eystathioy T, Selak S, et al. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies. Clin Immunol 2004;110:30-44. |
| Second level information |
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▶ The AC-22 pattern has been reported in small numbers of patients with a variety of conditions, including SjS, SLE, RA, MCTD, GPA, idiopathic cerebellar ataxia, paraneoplastic cerebellar degeneration, adult Still’s disease, and viral infections including HIV and EBV (29, 36-38) ▶ Although possibly biased by the referral pattern, one study concluded that the AC-22 pattern is not clinically associated with SARD as there were only 1 SjS and 2 RA diagnoses among their 20 AC-22 positive cases collected over 10-years and a clinical follow-up observation ranging from 0 – 10 years; the remaining cases showed diverse diagnoses including 2 carcinomas (37) ▶ The AC-22 pattern is rare in the general population (39) |
| Second level information references |
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29. Stinton LM, Eystathioy T, Selak S, et al. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies. Clin Immunol 2004;110:30-44. 36. Fritzler MJ, Etherington J, Sokolu, C, et al. Antibodies from patients with autoimmune disease react with a cytoplasmic antigen in the Golgi apparatus. J Immunol 1984;132:2904-8. 37. Vermeersch P, Van den Bergh K, Blockmans D, et al. Anti-Golgi autoantibodies are not clinically associated with systemic autoimmune diseases. Ann Rheum Dis 2011;70:234-5. 38. Staub HL, Souza F, Chan EKL, et al. Anti-Golgi antibodies in adult Still's disease. Clin Exp Rheumatol 2003;21:275-6. 39. Satoh M, Chan EKL, Ho LA, et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012;64:2319-27. |
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