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Previous Nomenclature | Centrioles |
Description | Distinct centrioles (1-2/cell) in cytoplasm and at the poles of mitotic spindle. |
Antigen Association | pericentrin, ninein, Cep250, Cep110 |
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
▶ The AC-24 pattern has low positive predictive value for any disease ▶ Within the spectrum of the SARD, the AC-24 pattern is found in patients with Raynaud’s phenomenon, localized scleroderma, SSc, SLE and RA, either alone or in combination with other SSc-associated antibodies (102–105) ▶ Antigens recognized include α-enolase, γ-enolase, ninein, Cep-250, Mob1, PCM-1/2, pericentrin; specific immunoassays for these autoantibodies are currently not commercially available (104, 106–108) |
First level information references |
102. Takahashi T, Asano Y, Hirakawa M, et al. Linear scleroderma with prominent multiple lymphadenopathy followed by the development of polymyositis: a case report and review of published work. J Dermatol 2016;43:1224-7. 103. Howng SL, Chou AK, Lin CC, et al. Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus. Mol Med Rep 2011;4:825-30. 104. Hamaguchi Y, Matsushita T, Hasegawa M, et al. High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies. Mod Rheumatol 2015;25:798-801. 105. Gavanescu I, Vazquez-Abad D, McCauley J, et al. Centrosome proteins: a major class of autoantigens in scleroderma. J Clin Immunol 1999;19:166-71. 106. Fritzler MJ, Zhang M, Stinton LM, et al. Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia. BMC Pediatr 2003;3. 107. Rattner JB, Martin L, Waisman DM, et al. Autoantibodies to the centrosome (centriole) react with determinants present in the glycolytic enzyme enolase. J Immunol 1991;146:2341-4. 108. Mack GJ, Rees J, Sandblom O, et al. Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. Arthritis Rheum 1998;41:551-8. |
Second level information |
▶ Possible association with infections; described in children with Mycoplasma pneumoniae infection (1) ▶ Possible association with malignancies; autoantibodies reacting with antigens in centrosomes are frequently found in sera of patients with breast cancer (2, 3) ▶ Autoantibodies to α-enolase, γ-enolase, Mob1, PCM-1/2, and pericentrin have been described in children with cerebellar ataxia after varicella infection; one patient with hyperthyroidism and vague muscle pain and one patient with Raynaud’s phenomenon, both without evidence of a SARD, had antibodies to α-enolase and γ-enolase (4.5) ▶ With respect to autoantibodies to ninein and Cep-250, there is no apparent correlation between serum autoantibody reactivity and the clinical diagnosis; reported in RA and SLE (6, 7) Notes: Most reports describe autoantibodies directly binding to specific antigens (i.e., antigen-specific immunoassays) and do not actually show correlations with the AC-24 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available. |
Second level information references |
1. Cimolai N, Mah D, Roland E. Anticentriolar autoantibodies in children with central nervous system manifestations of Mycoplasma pneumonia infection. J Neurol Neurosurg Psychiatry 1994;57:638-9. 2. Madrid FF, Maroun MC, Olivero OA, et al. Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis. BMC Cancer 2015;15:407. 3. Maroun MC, Olivero O, Lipovich L, et al. Anti-centrosome antibodies in breast cancer are the expression of autoimmunity. Immunol Res 2014;60:339-47. 4. Fritzler MJ, Zhang M, Stinton LM, et al. Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia. BMC Pediatr 2003;3:11. 5. Rattner JB, Martin L, Waisman DM, et al. Autoantibodies to the centrosome (centriole) react with determinants present in the glycolytic enzyme enolase. J Immunol 1991;146:2341-4. 6. Mack GJ, Rees J, Sandblom O, et al. Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. Arthritis Rheum 1998;41:551-8. 7. Howng SL, Chou AK, Lin CC, et al. Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus. Mol Med Rep 2011;4:825-30. |
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