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| Previous Nomenclature | Mitotic Spindle Apparatus |
| Description | The spindle fibers between the centrosomal poles are stained in mitotic cells, associated with cone-shaped decoration of the mitotic spindles. Spindle fibers are observed in both NuMA-like and non-NuMA patterns. NuMA-like pattern has an associated distinct nuclear speckled pattern. Only non-NuMA patterns are shown here while NuMA-like patterns are shown in the NuMA-like group |
| Antigen Association | Antigen recognized includes HsEg5; specific immunoassays for this autoantibody, or other spindle fiber targets, are currently not commercially available [1, 2] |
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Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
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▶ The AC-25 pattern has low positive predictive value for any disease [3]. ▶ Found very infrequently in a routine diagnostic setting [3]. |
| First level information references |
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| Second level information |
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▶ While AC-25 is not associated with a defined autoimmune disease, reactivity with HsEg5 is more commonly found in systemic lupus erythematosus and Sjögren disease [1, 2]. |
| Second level information references |
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1. Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB. The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus. Arthritis Rheum. 1996;39:1635-42. 2. Szalat R, Ghillani-Dalbin P, Jallouli M, Amoura Z, Musset L, Cacoub P, Sene D. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: Clinical and immunological features: A propos of 40 new cases and review of the literature. Autoimmun Rev. 2010;9:652-6. 3. Mozo L, Gutierrez C, Gomez J. Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies. J Clin Immunol. 2008;28:285-90. |
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