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Previous Nomenclature | MSA-1, centrophilin |
Description | Nuclear speckled staining with spindle fibers. |
Antigen Association | NuMA |
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
▶ Approximately one-half of the patients with the AC-26 pattern have clinical features of a SARD (SjS, SLE, UCTD, limited SSc, or RA); the AC-26 pattern is also observed in patients with organ-specific autoimmune diseases and less frequently in non-autoimmune conditions, especially when in low titer (109, 111–114) ▶ Found very infrequently in a routine serology diagnostic setting (109) ▶ Antigens recognized include NuMA, centrophilin, SP-H antigen and NMP-22; specific immunoassays for these autoantibodies are currently not commercially available (115) |
First level information references |
109. Mozo L, Gutiérrez C, Gómez J, Gómez Jesús. Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies. J Clin Immunol 2008;28:285-90. 111. Szalat R, Ghillani-Dalbin P, Jallouli M, et al. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: clinical and Immunological features: a propos of 40 new cases and review of the literature. Autoimmun Rev 2010;9:652-6. 112. Grypiotis P, Ruffatti A, Tonello M, et al. [Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with rheumatic diseases]. Reumatismo 2002;54:232-7. 113. Price CM, McCarty GA, Pettijohn DE. NuMA protein is a human autoantigen. Arthritis Rheum 1984;27:774-9. 114. Bonaci-Nikolic B, Andrejevic S, Bukilica M, et al. Autoantibodies to mitotic apparatus: association with other autoantibodies and their clinical significance. J Clin Immunol 2006;26:438-46. 115. Compton DA, Szilak I, Cleveland DW. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol 1992;116:1395-408. |
Second level information |
None |
Second level information references |
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FAQ |
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