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| Previous Nomenclature | Stem body, midbody |
| Description | Staining of the intercellular bridge that connects daughter cells during cell division but dissipates when cells are completely separated |
| Antigen Association | CENP-E, CENP-F, TD60, MSA36, KIF-14, MKLP-1, MPP1/KIF20B, and INCENP. Some human sera with CENP-F autoantibodies also demonstrate anti-stem body/midbody staining but there is no evidence that this staining is CENP-F itself |
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Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
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▶ The AC-27 pattern has low positive predictive value for any disease [1]. ▶ Found infrequently in a routine diagnostic setting [2]. ▶ Specific immunoassays for autoantibodies to recognized antigens are currently not commercially available [1, 3]. |
| Second level information |
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▶ Described in patients with systemic sclerosis (SSc), Raynaud’s phenomenon, and malignancy [2, 4, 5]. ▶ Autoantibodies to CENP-E, CENP-F, TD60, MSA36, KIF-14, and MKLP-1 have been described in patients with SSc (limited and diffuse), systemic lupus erythematosus, and malignancies [1, 6]. ▶ Autoantibodies to INCENP have been described in a single patient with Graham-Little-Piccardi-Lasseur Syndrome [3]. ▶ Autoantibodies to MPP1 /KIF20B (M-phase phosphoprotein 1) have been described in patients with idiopathic ataxia, other neurological syndromes and paroxysmal nocturnal hemoglobinuria [7, 8]. Notes: Most reports describe autoantibodies directly binding to specific antigens (i.e., antigen-specific immunoassays) and do not actually show correlations with the AC-27 pattern as such. |
| References |
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1. Rattner JB, Mack GJ, Fritzler MJ. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep. 1998;25:143-55. 2. Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev. 2013;12:998-1003. 3. Rodriguez-Bayona B, Ruchaud S, Rodriguez C, Linares M, Astola A, Ortiz M, Earnshaw WC, Valdivia MM. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis. 2007;4:1. 4. Fritzler MJ, Ayer LM, Gohill J, O'Connor C, Laxer RM, Humbel RL. An antigen in metaphase chromatin and the midbody of mammalian cells binds to scleroderma sera. J Rheumatol. 1987;14:291-4. 5. Tausche AK, Conrad K, Seidel W, Roch B. Anti-midbody antibodies as a possible predictive factor for a special limited or abortive form of systemic sclerosis? Ann Rheum Dis. 2005;64:1237-8. 6. Fritzler MJ, Rattner JB, Luft LM, Edworthy SM, Casiano CA, Peebles C, Mahler M. Historical perspectives on the discovery and elucidation of autoantibodies to centromere proteins (CENP) and the emerging importance of antibodies to CENP-F. Autoimmun Rev. 2011;10:194-200. 7. Fritzler MJ, Kerfoot SM, Feasby TE, Zochodne DW, Westendorf JM, Dalmau JO, Chan EKL. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1). J Investig Med. 2000;48:28-39. 8. Alahmad A, Preuss KD, Schenk J, Fureder W, Schrezenmeier H, Muller-Lantzsch N, Schubert J, Pfreundschuh M. Desmoplakin and KIF20B as target antigens in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2010;151:273-80. |
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