ICAP
AC-28 - Mitotic chromosomal
Previous Nomenclature chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA)
Description Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells.
Antigen Association modified histone H3, MCA-1
Clinical Relevance
First level information
About Clinical Relevance

The AC-28 pattern has low positive predictive value for any disease

Found very infrequently in a routine serology diagnostic setting (120)

Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available (120–122)

First level information references
120.
Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.
121.
Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.
122.
Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.
Second level information

Autoantibodies to DCA have been described in patients with SLE (18)

Autoantibodies to MCA1 have been described in patients with carcinoma (19)

Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica (20)

Second level information references
18.
Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329-38.
19.
Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71-80.
20.
Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172-82.
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Online since 19 May 2015