AC-4 - Nuclear fine speckled
Synonym fine granular
Antigen Association SS-A/Ro, SS-B/La, Mi-2, TIF1γ, TIF1β, Ku
Disease Association SjS, SLE, dermatomyositis
Description Fine tiny speckles across all nucleoplasm. The nucleoli may be stained or not stained. Mitotic cells (metaphase, anaphase, and telophase) have the chromatin mass not stained. e.g. anti-SS-A/Ro, anti-SS-B/La


Ro/SS-A and La/SS-B negative in HEp-2 IFA. Can I get positive Ro and La with negative ANA IFA? How to explain if yes?

Online since 19 May 2015